Innovative Methods Program for Advancing Clinical Trials (IMPACT)

A joint venture of the University of North Carolina at Chapel Hill,
Duke University and North Carolina State University.
IMPACT is a comprehensive program that aims to dramatically improve the health and longevity of people by improving the clinical trial process.

The primary source of funding for this project is the National Cancer Institute through a program project (P01 CA142538) grant entitled "Statistical Methods for Cancer Clinical Trials."

Our approach is to leverage recent advances in statistical and computational science to create new clinical trial designs and data analysis tools that resolve many of the key scientific limitations of current clinical trial methodology.

Our research focuses on:
1. practical design and analysis problems in Phase II and Phase III clinical trials,
2. the problem of missing data and efficient use of prognostic information,
3. post-marketing surveillance and comparative effectiveness research using clinical trial data,
4. pharamcogenetics and individualized therapies, and
5. the potential of dynamic treatment regimes to improve cancer treatment.