CRM2DIM: Dual-Agent Bayesian Continual Reassessment Method (SAS)

TitleCRM2DIM: Dual-Agent Bayesian Continual Reassessment Method (SAS)
Publication TypeSoftware
Year of Publication2019
AuthorsBayar, Mohamed, Anastasia Ivanova, and Gwenael Le Teuff

The continual reassessment method (CRM) is a model-based dose-finding design for single-agent phase I oncology trials. With the advance of targeted therapies in oncology, more and more phase I trials investigate drug combinations
rather than a single agent in order to find one or more maximum tolerated dose combinations. Several designs have been proposed for such dose-finding trials but only a few software packages are available to implement them. One of the designs is the two-dimensional Bayesian CRM proposed by Wang and Ivanova. This macro can be used to run a phase I
dose-finding trial for two-drug combination and to perform simulations.