FADTTS: functional analysis of diffusion tensor tract statistics.

TitleFADTTS: functional analysis of diffusion tensor tract statistics.
Publication TypeJournal Article
Year of Publication2011
AuthorsZhu, Hongtu, Linglong Kong, Runze Li, Martin Styner, Guido Gerig, Weili Lin, and John H. Gilmore
JournalNeuroimage
Volume56
Issue3
Pagination1412-25
Date Published2011 Jun 01
ISSN1095-9572
KeywordsAlgorithms, Anisotropy, Brain, Computer Simulation, Diffusion Tensor Imaging, Female, Gestational Age, Humans, Image Processing, Computer-Assisted, Infant, Internal Capsule, Least-Squares Analysis, Male, Monte Carlo Method, Multivariate Analysis, Neural Pathways, Normal Distribution, Principal Component Analysis, Sex Characteristics, Uncertainty
Abstract

The aim of this paper is to present a functional analysis of a diffusion tensor tract statistics (FADTTS) pipeline for delineating the association between multiple diffusion properties along major white matter fiber bundles with a set of covariates of interest, such as age, diagnostic status and gender, and the structure of the variability of these white matter tract properties in various diffusion tensor imaging studies. The FADTTS integrates five statistical tools: (i) a multivariate varying coefficient model for allowing the varying coefficient functions in terms of arc length to characterize the varying associations between fiber bundle diffusion properties and a set of covariates, (ii) a weighted least squares estimation of the varying coefficient functions, (iii) a functional principal component analysis to delineate the structure of the variability in fiber bundle diffusion properties, (iv) a global test statistic to test hypotheses of interest, and (v) a simultaneous confidence band to quantify the uncertainty in the estimated coefficient functions. Simulated data are used to evaluate the finite sample performance of FADTTS. We apply FADTTS to investigate the development of white matter diffusivities along the splenium of the corpus callosum tract and the right internal capsule tract in a clinical study of neurodevelopment. FADTTS can be used to facilitate the understanding of normal brain development, the neural bases of neuropsychiatric disorders, and the joint effects of environmental and genetic factors on white matter fiber bundles. The advantages of FADTTS compared with the other existing approaches are that they are capable of modeling the structured inter-subject variability, testing the joint effects, and constructing their simultaneous confidence bands. However, FADTTS is not crucial for estimation and reduces to the functional analysis method for the single measure.

DOI10.1016/j.neuroimage.2011.01.075
Alternate JournalNeuroimage
Original PublicationFADTTS: Functional analysis of diffusion tensor tract statistics.
PubMed ID21335092
PubMed Central IDPMC3085665
Grant ListP50 MH064065-04 / MH / NIMH NIH HHS / United States
R41 NS059095-02 / NS / NINDS NIH HHS / United States
HD053000 / HD / NICHD NIH HHS / United States
R01 MH086633 / MH / NIMH NIH HHS / United States
R01 NS055754-04 / NS / NINDS NIH HHS / United States
P01 CA142538 / CA / NCI NIH HHS / United States
R01 MH070890-04 / MH / NIMH NIH HHS / United States
R01 MH070890-07 / MH / NIMH NIH HHS / United States
R01 HD053000-03S1 / HD / NICHD NIH HHS / United States
R21 AG033387-02 / AG / NIA NIH HHS / United States
AG033387 / AG / NIA NIH HHS / United States
MH070890 / MH / NIMH NIH HHS / United States
R01 NS055754-01A1 / NS / NINDS NIH HHS / United States
R21 DA024260-03 / DA / NIDA NIH HHS / United States
HD 03110 / HD / NICHD NIH HHS / United States
R01 HD053000-05 / HD / NICHD NIH HHS / United States
P50 DA010075 / DA / NIDA NIH HHS / United States
R01 HD053000-04 / HD / NICHD NIH HHS / United States
P50 MH064065-09 / MH / NIMH NIH HHS / United States
R01 MH070890-03 / MH / NIMH NIH HHS / United States
R42 NS059095 / NS / NINDS NIH HHS / United States
R01 MH086633-02 / MH / NIMH NIH HHS / United States
P50 MH064065-05 / MH / NIMH NIH HHS / United States
R01 HD053000-01A1 / HD / NICHD NIH HHS / United States
R01 MH091645-01A1 / MH / NIMH NIH HHS / United States
P01 DA022446 / DA / NIDA NIH HHS / United States
U54 EB005149 / EB / NIBIB NIH HHS / United States
R01 NS055754-05 / NS / NINDS NIH HHS / United States
R01NS055754 / NS / NINDS NIH HHS / United States
P50 MH064065-03 / MH / NIMH NIH HHS / United States
R41 NS059095 / NS / NINDS NIH HHS / United States
R42 NS059095-04 / NS / NINDS NIH HHS / United States
R01 HD053000-03 / HD / NICHD NIH HHS / United States
R01 MH086633-03 / MH / NIMH NIH HHS / United States
R01 MH091645-02 / MH / NIMH NIH HHS / United States
R21 DA024260-02 / DA / NIDA NIH HHS / United States
R21 AG033387-01A1 / AG / NIA NIH HHS / United States
R01 MH070890-06A1 / MH / NIMH NIH HHS / United States
R42 NS059095-03 / NS / NINDS NIH HHS / United States
P01CA142538-01 / CA / NCI NIH HHS / United States
P50 MH064065 / MH / NIMH NIH HHS / United States
R01 MH086633-01A1 / MH / NIMH NIH HHS / United States
R01 NS055754 / NS / NINDS NIH HHS / United States
RR025747-01 / RR / NCRR NIH HHS / United States
P50 MH064065-07 / MH / NIMH NIH HHS / United States
P50 MH064065-08 / MH / NIMH NIH HHS / United States
R01 MH070890-05S1 / MH / NIMH NIH HHS / United States
R01EB5-34816 / EB / NIBIB NIH HHS / United States
R01 MH070890-01 / MH / NIMH NIH HHS / United States
P30 HD003110 / HD / NICHD NIH HHS / United States
R21 DA024260-01 / DA / NIDA NIH HHS / United States
P50 MH064065-10 / MH / NIMH NIH HHS / United States
R01 MH070890 / MH / NIMH NIH HHS / United States
P50-DA10075 / DA / NIDA NIH HHS / United States
R01 HD053000-02 / HD / NICHD NIH HHS / United States
R01 HD053000 / HD / NICHD NIH HHS / United States
P50 MH064065-06 / MH / NIMH NIH HHS / United States
R21 DA024260 / DA / NIDA NIH HHS / United States
U01 MH070890 / MH / NIMH NIH HHS / United States
MH086633 / MH / NIMH NIH HHS / United States
R01 MH091645 / MH / NIMH NIH HHS / United States
UL1 RR025747 / RR / NCRR NIH HHS / United States
R01 MH070890-05 / MH / NIMH NIH HHS / United States
R01 MH070890-02 / MH / NIMH NIH HHS / United States
R21 DA024260-04 / DA / NIDA NIH HHS / United States
R01 NS055754-03 / NS / NINDS NIH HHS / United States
R21 AG033387 / AG / NIA NIH HHS / United States
R41 NS059095-01 / NS / NINDS NIH HHS / United States
R01 NS055754-02 / NS / NINDS NIH HHS / United States
R21-DA024260 / DA / NIDA NIH HHS / United States
MH064065 / MH / NIMH NIH HHS / United States
U54 EB005149-01 / EB / NIBIB NIH HHS / United States
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