Multivariate longitudinal shape analysis of human lateral ventricles during the first twenty-four months of life.

TitleMultivariate longitudinal shape analysis of human lateral ventricles during the first twenty-four months of life.
Publication TypeJournal Article
Year of Publication2014
AuthorsBompard, Lucile, Shun Xu, Martin Styner, Beatriz Paniagua, Mihye Ahn, Ying Yuan, Valerie Jewells, Wei Gao, Dinggang Shen, Hongtu Zhu, and Weili Lin
JournalPLoS One
Volume9
Issue9
Paginatione108306
Date Published2014
ISSN1932-6203
KeywordsCerebrum, Child, Preschool, Female, Humans, Infant, Lateral Ventricles, Magnetic Resonance Imaging, Male, Multivariate Analysis
Abstract

BACKGROUND: Little is known about the temporospatial shape characteristics of human lateral ventricles (LVs) during the first two years of life. This study aimed to delineate the morphological growth characteristics of LVs during early infancy using longitudinally acquired MR images in normal healthy infants.METHODS: 24 healthy infants were MR imaged starting from 2 weeks old every 3 months during the first and every 6 months during the second year. Bilateral LVs were segmented and longitudinal morphological and shape analysis were conducted using longitudinal mixed effect models.RESULTS: A significant bilateral ventricular volume increase (p<0.0001) is observed in year one (Left: 126±51% and Right: 145±62%), followed by a significant reduction (p<0.02) during the second year of life (Left: -24±27% and Right: -20±18%) despite the continuing increase of intracranial volume. Morphological analysis reveals that the ventricular growth is spatially non-uniform, and that the most significant growth occurs during the first 6 months. The first 3 months of life exhibit a significant (p<0.01) bilateral lengthening of the anterior lateral ventricle and a significant increase of radius (p<0.01) and area (p<0.01) at the posterior portion of the ventricle. Shape analysis shows that the horns exhibit a faster growth rate than the mid-body. Finally, bilateral significant age effects (p<0.01) are observed for the growth of LVs whereas gender effects are more subtle and significant effects (p<0.01) only present at the left anterior and posterior horns. More importantly, both the age and gender effects are growth directionally dependent.CONCLUSIONS: We have demonstrated the temporospatial shape growth characteristics of human LVs during the first two years of life using a unique longitudinal MR data set. A temporally and spatially non-uniform growth pattern was reported. These normative results could provide invaluable information to discern abnormal growth patterns in patients with neurodevelopmental disorders.

DOI10.1371/journal.pone.0108306
Alternate JournalPLoS One
Original PublicationMultivariate longitudinal shape analysis of human lateral ventricles during the first twenty-four months of life.
PubMed ID25265017
PubMed Central IDPMC4180454
Grant ListP01CA142538-01 / CA / NCI NIH HHS / United States
R01 MH086633 / MH / NIMH NIH HHS / United States
U54 HD079124 / HD / NICHD NIH HHS / United States
R01 EB009634 / EB / NIBIB NIH HHS / United States
U54 EB005149 / EB / NIBIB NIH HHS / United States
R01NS055754 / NS / NINDS NIH HHS / United States
R01 AG042599 / AG / NIA NIH HHS / United States
EB005149-01 / EB / NIBIB NIH HHS / United States
P50 MH064065 / MH / NIMH NIH HHS / United States
R01 NS055754 / NS / NINDS NIH HHS / United States
RR025747-01 / RR / NCRR NIH HHS / United States
MH086633 / MH / NIMH NIH HHS / United States
UL1 RR025747 / RR / NCRR NIH HHS / United States
P01 CA142538 / CA / NCI NIH HHS / United States
R01 MH100217 / MH / NIMH NIH HHS / United States
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