Comment.

TitleComment.
Publication TypeJournal Article
Year of Publication2016
AuthorsChen, Jingxiang, Yufeng Liu, Donglin Zeng, Rui Song, Yingqi Zhao, and Michael R. Kosorok
JournalJ Am Stat Assoc
Volume111
Issue515
Pagination942-947
Date Published2016
ISSN0162-1459
Abstract

Xu, Müller, Wahed, and Thall proposed a Bayesian model to analyze an acute leukemia study involving multi-stage chemotherapy regimes. We discuss two alternative methods, Q-learning and O-learning, to solve the same problem from the machine learning point of view. The numerical studies show that these methods can be flexible and have advantages in some situations to handle treatment heterogeneity while being robust to model misspecification.

DOI10.1080/01621459.2016.1200914
Alternate JournalJ Am Stat Assoc
Original PublicationComment on ``Bayesian nonparametric estimation for dynamic treatment regimes with sequential transition tmes, by Xu, Y., Muller, P. Wahed, AS and Thall, PF.''
PubMed ID28003710
PubMed Central IDPMC5167482
Grant ListP01 CA142538 / CA / NCI NIH HHS / United States
R01 DK108073 / DK / NIDDK NIH HHS / United States