JOINT STRUCTURE SELECTION AND ESTIMATION IN THE TIME-VARYING COEFFICIENT COX MODEL.

TitleJOINT STRUCTURE SELECTION AND ESTIMATION IN THE TIME-VARYING COEFFICIENT COX MODEL.
Publication TypeJournal Article
Year of Publication2016
AuthorsXiao, Wei, Wenbin Lu, and Hao Helen Zhang
JournalStat Sin
Volume26
Issue2
Pagination547-567
Date Published2016 Apr
ISSN1017-0405
Abstract

Time-varying coefficient Cox model has been widely studied and popularly used in survival data analysis due to its flexibility for modeling covariate effects. It is of great practical interest to accurately identify the structure of covariate effects in a time-varying coefficient Cox model, i.e. covariates with null effect, constant effect and truly time-varying effect, and estimate the corresponding regression coefficients. Combining the ideas of local polynomial smoothing and group nonnegative garrote, we develop a new penalization approach to achieve such goals. Our method is able to identify the underlying true model structure with probability tending to one and simultaneously estimate the time-varying coefficients consistently. The asymptotic normalities of the resulting estimators are also established. We demonstrate the performance of our method using simulations and an application to the primary biliary cirrhosis data.

DOI10.5705/ss.2013.076
Alternate JournalStat Sin
Original PublicationJoint structure selection and estimation in the time-varying coefficient Cox model.
PubMed ID27540275
PubMed Central IDPMC4987133
Grant ListP01 CA142538 / CA / NCI NIH HHS / United States
R01 CA140632 / CA / NCI NIH HHS / United States