Embracing rejection: Immunologic trends in brain metastasis.

TitleEmbracing rejection: Immunologic trends in brain metastasis.
Publication TypeJournal Article
Year of Publication2016
AuthorsS Farber, Harrison, Vadim Tsvankin, Jessica L. Narloch, Grace J. Kim, April K. S. Salama, Gordana Vlahovic, Kimberly L. Blackwell, John P. Kirkpatrick, and Peter E. Fecci
Date Published2016 Jul

Brain metastases represent the most common type of brain tumor. These tumors offer a dismal prognosis and significantly impact quality of life for patients. Their capacity for central nervous system (CNS) invasion is dependent upon induced disruptions to the blood-brain barrier (BBB), alterations to the brain microenvironment, and mechanisms for escaping CNS immunosurveillance. In the emerging era of immunotherapy, understanding how metastases are influenced by the immunologic peculiarities of the CNS will be crucial to forging therapeutic advances. In this review, the immunology of brain metastasis is explored.

Alternate JournalOncoimmunology
Original PublicationEmbracing rejection: Immunologic trends in brain metastasis.
PubMed ID27622023
PubMed Central IDPMC5006920
Grant ListP01 CA142538 / CA / NCI NIH HHS / United States