Title | The Change-Plane Cox Model. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Wei, Susan, and Michael R. Kosorok |
Journal | Biometrika |
Volume | 105 |
Issue | 4 |
Pagination | 891-903 |
Date Published | 2018 Dec |
ISSN | 0006-3444 |
Abstract | We propose a projection pursuit technique in survival analysis for finding lower-dimensional projections that exhibit differentiated survival outcome. This idea is formally introduced as the change-plane Cox model, a non-regular Cox model with a change-plane in the covariate space dividing the population into two subgroups whose hazards are proportional. The proposed technique offers a potential framework for principled subgroup discovery. Estimation of the change-plane is accomplished via likelihood maximization over a data-driven sieve constructed using sliced inverse regression. Consistency of the sieve procedure for the change-plane parameters is established. In simulations the sieve estimator demonstrates better classification performance for subgroup identification than alternatives. |
DOI | 10.1093/biomet/asy050 |
Alternate Journal | Biometrika |
Original Publication | The change-plane Cox model. |
PubMed ID | 30555175 |
PubMed Central ID | PMC6289527 |
Grant List | P01 CA142538 / CA / NCI NIH HHS / United States |
The Change-Plane Cox Model.
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