Title | Intrinsic Regression Models for Medial Representation of Subcortical Structures. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Shi, Xiaoyan, Hongtu Zhu, Joseph G. Ibrahim, Faming Liang, Jeffrey Lieberman, and Martin Styner |
Journal | J Am Stat Assoc |
Volume | 107 |
Issue | 497 |
Pagination | 12-23 |
Date Published | 2012 Mar 01 |
ISSN | 0162-1459 |
Abstract | The aim of this paper is to develop a semiparametric model for describing the variability of the medial representation of subcortical structures, which belongs to a Riemannian manifold, and establishing its association with covariates of interest, such as diagnostic status, age and gender. We develop a two-stage estimation procedure to calculate the parameter estimates. The first stage is to calculate an intrinsic least squares estimator of the parameter vector using the annealing evolutionary stochastic approximation Monte Carlo algorithm and then the second stage is to construct a set of estimating equations to obtain a more efficient estimate with the intrinsic least squares estimate as the starting point. We use Wald statistics to test linear hypotheses of unknown parameters and establish their limiting distributions. Simulation studies are used to evaluate the accuracy of our parameter estimates and the finite sample performance of the Wald statistics. We apply our methods to the detection of the difference in the morphological changes of the left and right hippocampi between schizophrenia patients and healthy controls using medial shape description. |
DOI | 10.1080/01621459.2011.643710 |
Alternate Journal | J Am Stat Assoc |
Original Publication | Intrinsic regression models for medial representation of subcortical structures. |
PubMed ID | 23794769 |
PubMed Central ID | PMC3685886 |
Grant List | U54 EB005149 / EB / NIBIB NIH HHS / United States P30 HD003110 / HD / NICHD NIH HHS / United States R01 CA074015-12 / CA / NCI NIH HHS / United States UL1 RR025747 / RR / NCRR NIH HHS / United States T32 CA106209 / CA / NCI NIH HHS / United States P01 CA142538 / CA / NCI NIH HHS / United States R01 GM070335-14 / GM / NIGMS NIH HHS / United States R01 CA074015-11A1 / CA / NCI NIH HHS / United States R21 AG033387-02 / AG / NIA NIH HHS / United States R01 CA074015-04A1 / CA / NCI NIH HHS / United States P30 HD003110-40 / HD / NICHD NIH HHS / United States R01 GM070335-13A1 / GM / NIGMS NIH HHS / United States R01 CA074015-09 / CA / NCI NIH HHS / United States P01 CA142538-01 / CA / NCI NIH HHS / United States R01 GM070335-12 / GM / NIGMS NIH HHS / United States R01 CA074015-06 / CA / NCI NIH HHS / United States R41 NS059095-02 / NS / NINDS NIH HHS / United States T32 CA106209-04 / CA / NCI NIH HHS / United States R01 CA074015-05 / CA / NCI NIH HHS / United States R42 NS059095 / NS / NINDS NIH HHS / United States R01 MH091645-03 / MH / NIMH NIH HHS / United States R01 MH086633-02 / MH / NIMH NIH HHS / United States R01 MH091645-01A1 / MH / NIMH NIH HHS / United States R01 CA074015-03 / CA / NCI NIH HHS / United States R01 GM070335-08 / GM / NIGMS NIH HHS / United States R41 NS059095 / NS / NINDS NIH HHS / United States R42 NS059095-04 / NS / NINDS NIH HHS / United States R01 MH086633-03 / MH / NIMH NIH HHS / United States R01 GM070335-10 / GM / NIGMS NIH HHS / United States R01 MH091645-02 / MH / NIMH NIH HHS / United States R21 AG033387-01A1 / AG / NIA NIH HHS / United States U54 EB005149-05 / EB / NIBIB NIH HHS / United States T32 CA106209-05 / CA / NCI NIH HHS / United States R42 NS059095-03 / NS / NINDS NIH HHS / United States UL1 RR025747-01 / RR / NCRR NIH HHS / United States R01 CA070101-06 / CA / NCI NIH HHS / United States R01 MH086633 / MH / NIMH NIH HHS / United States R01 GM070335-09 / GM / NIGMS NIH HHS / United States R01 CA074015-10 / CA / NCI NIH HHS / United States T32 CA106209-01 / CA / NCI NIH HHS / United States R01 MH086633-01A1 / MH / NIMH NIH HHS / United States R01 GM070335 / GM / NIGMS NIH HHS / United States R01 GM070335-11 / GM / NIGMS NIH HHS / United States R01 CA070101-05 / CA / NCI NIH HHS / United States T32 CA106209-07 / CA / NCI NIH HHS / United States R01 GM070335-07A1 / GM / NIGMS NIH HHS / United States R01 CA070101-04 / CA / NCI NIH HHS / United States R01 CA074015-08A2 / CA / NCI NIH HHS / United States T32 CA106209-03 / CA / NCI NIH HHS / United States T32 CA106209-02 / CA / NCI NIH HHS / United States R21 AG033387 / AG / NIA NIH HHS / United States R01 CA074015-07 / CA / NCI NIH HHS / United States T32 CA106209-06A2 / CA / NCI NIH HHS / United States R01 CA074015 / CA / NCI NIH HHS / United States R41 NS059095-01 / NS / NINDS NIH HHS / United States |
Intrinsic Regression Models for Medial Representation of Subcortical Structures.
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