Title | Diffusion tensor imaging-based characterization of brain neurodevelopment in primates. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Shi, Yundi, Sarah J. Short, Rebecca C. Knickmeyer, Jiaping Wang, Christopher L. Coe, Marc Niethammer, John H. Gilmore, Hongtu Zhu, and Martin A. Styner |
Journal | Cereb Cortex |
Volume | 23 |
Issue | 1 |
Pagination | 36-48 |
Date Published | 2013 Jan |
ISSN | 1460-2199 |
Keywords | Aging, Animals, Brain, Diffusion Tensor Imaging, Female, Macaca mulatta, Male, Nerve Fibers, Myelinated, Neurons, Organ Size |
Abstract | Primate neuroimaging provides a critical opportunity for understanding neurodevelopment. Yet the lack of a normative description has limited the direct comparison with changes in humans. This paper presents for the first time a cross-sectional diffusion tensor imaging (DTI) study characterizing primate brain neurodevelopment between 1 and 6 years of age on 25 healthy undisturbed rhesus monkeys (14 male, 11 female). A comprehensive analysis including region-of-interest, voxel-wise, and fiber tract-based approach demonstrated significant changes of DTI properties over time. Changes in fractional anisotropy (FA), mean diffusivity, axial diffusivity (AD), and radial diffusivity (RD) exhibited a heterogeneous pattern across different regions as well as along fiber tracts. Most of these patterns are similar to those from human studies yet a few followed unique patterns. Overall, we observed substantial increase in FA and AD and a decrease in RD for white matter (WM) along with similar yet smaller changes in gray matter (GM). We further observed an overall posterior-to-anterior trend in DTI property changes over time and strong correlations between WM and GM development. These DTI trends provide crucial insights into underlying age-related biological maturation, including myelination, axonal density changes, fiber tract reorganization, and synaptic pruning processes. |
DOI | 10.1093/cercor/bhr372 |
Alternate Journal | Cereb Cortex |
Original Publication | Diffusion tensor imaging-based characterization of brain neurodevelopment in primates. |
PubMed ID | 22275483 |
PubMed Central ID | PMC3513950 |
Grant List | T32 HD40127 / HD / NICHD NIH HHS / United States HD053000 / HD / NICHD NIH HHS / United States P01 CA142538-01 / CA / NCI NIH HHS / United States EB005149-01 / EB / NIBIB NIH HHS / United States RR025747-01 / RR / NCRR NIH HHS / United States P50 MH064065 / MH / NIMH NIH HHS / United States P50 MH078105 / MH / NIMH NIH HHS / United States AG 033387 / AG / NIA NIH HHS / United States UL1-RR025747-01 / RR / NCRR NIH HHS / United States U54 EB005149-01 / EB / NIBIB NIH HHS / United States AG033387 / AG / NIA NIH HHS / United States P50 MH078105-01A2S1 / MH / NIMH NIH HHS / United States P30 HD003352 / HD / NICHD NIH HHS / United States MH070890 / MH / NIMH NIH HHS / United States P01 DA022446 / DA / NIDA NIH HHS / United States P30 HD03110 / HD / NICHD NIH HHS / United States T32 MH019111-13 / MH / NIMH NIH HHS / United States P01CA142538-01 / CA / NCI NIH HHS / United States AI067518 / AI / NIAID NIH HHS / United States HD039386 / HD / NICHD NIH HHS / United States R01 MH086633 / MH / NIMH NIH HHS / United States MH086633 / MH / NIMH NIH HHS / United States R01 MH091645 / MH / NIMH NIH HHS / United States P01 CA142538 / CA / NCI NIH HHS / United States K01 MH083045-01 / MH / NIMH NIH HHS / United States |
Diffusion tensor imaging-based characterization of brain neurodevelopment in primates.
Project: