Title | Bayesian Model Assessment in Joint Modeling of Longitudinal and Survival Data with Applications to Cancer Clinical Trials. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Zhang, Danjie, Ming-Hui Chen, Joseph G. Ibrahim, Mark E. Boye, and Wei Shen |
Journal | J Comput Graph Stat |
Volume | 26 |
Issue | 1 |
Pagination | 121-133 |
Date Published | 2017 |
ISSN | 1061-8600 |
Abstract | Joint models for longitudinal and survival data are routinely used in clinical trials or other studies to assess a treatment effect while accounting for longitudinal measures such as patient-reported outcomes (PROs). In the Bayesian framework, the deviance information criterion (DIC) and the logarithm of the pseudo marginal likelihood (LPML) are two well-known Bayesian criteria for comparing joint models. However, these criteria do not provide separate assessments of each component of the joint model. In this paper, we develop a novel decomposition of DIC and LPML to assess the fit of the longitudinal and survival components of the joint model, separately. Based on this decomposition, we then propose new Bayesian model assessment criteria, namely, ΔDIC and ΔLPML, to determine the importance and contribution of the longitudinal (survival) data to the model fit of the survival (longitudinal) data. Moreover, we develop an efficient Monte Carlo method for computing the Conditional Predictive Ordinate (CPO) statistics in the joint modeling setting. A simulation study is conducted to examine the empirical performance of the proposed criteria and the proposed methodology is further applied to a case study in mesothelioma. |
DOI | 10.1080/10618600.2015.1117472 |
Alternate Journal | J Comput Graph Stat |
Original Publication | Bayesian model assessment in joint modeling of longitudinal and survival data with applications to cancer clinical trials. |
PubMed ID | 28239247 |
PubMed Central ID | PMC5321618 |
Grant List | P01 CA142538 / CA / NCI NIH HHS / United States R01 GM070335 / GM / NIGMS NIH HHS / United States |
Bayesian Model Assessment in Joint Modeling of Longitudinal and Survival Data with Applications to Cancer Clinical Trials.
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